A plain-language guide to help you understand the terms, record how your week went and prepare for a conversation with your health team.
Version 1.4 · October 2026 · Prototype
Retatrutide is investigational. It has not been approved by Health Canada or by any other regulator, and it cannot be lawfully sold to consumers. Outside an authorized clinical trial, products sold as retatrutide are unapproved and unverified.
Source: Lilly Canada public safety notice, as reported by CTV News, 17 August 2026.
This guide helps you learn and keep records. It does not recommend a dose, and it does not replace your health team.
A peptide is a short chain of amino acids, the same building blocks that make up proteins. Several of the body's own hormones are peptides, including insulin. Some medicines are peptides designed to act like those hormones.
Retatrutide is an investigational medicine developed by Eli Lilly and given as a once-weekly injection in clinical trials. It acts on three hormone receptors involved in appetite and metabolism (GIP, GLP-1 and glucagon). It is being studied for obesity, type 2 diabetes and related conditions. It is not an approved treatment.
The terms you are likely to hear, how the three measurements (mg, mL and syringe markings) differ, and how your appetite and symptoms change from week to week. The check-in turns your answers into a short summary and a list of questions you can bring to an appointment.
Whether you take retatrutide at all, the amount, the schedule, how it is prepared and what to do about any symptom. This guide never decides those things. If something here differs from what your health team has told you, follow your health team.
Questions marked optional can be left blank. Where you are unsure, choose "I don't know" rather than guessing.
Describe what you experienced, compared with before you started.
A lower appetite often brings a lower thirst, so think about fluids as well as food.
Food noise means frequent or persistent thoughts about food. This records your preference so you can raise it with your health team. It does not change anything by itself.
Select everything that applies. These are recorded as observations. Whether a change is helpful depends on context, such as whether you are still eating enough.
Select everything that applies. You will be asked a few short questions about each one.
Your answers are not saved. Nothing you enter is stored or sent anywhere. Closing or reloading this page clears everything, so download, print or copy your summary if you want to keep it.
Complete the check-in and select "Create my summary". You will see what you reported, what needs attention, why, and questions to bring to your health team.
This summary is out of date. Your answers changed after it was created.
This calculator is a learning tool. It is separate from the check-in and you do not need it to create a summary. It does not recommend an amount or tell you how to mix anything.
Reconstitution means mixing a powder with a specified liquid. The resulting concentration is the amount of medicine in each millilitre of liquid.
Syringe markings measure liquid volume. They are sometimes called "units" or "IU", but they do not describe the strength of the medicine. Always check the physical syringe scale independently.
| Week | Appetite | Eating & drinking | Symptoms | Weight |
|---|---|---|---|---|
| 1 | About the same | Yes | None | 92.4 kg |
| 2 | Changes day to day | Yes | None | 92.1 kg |
| 3 | Lower, comfortable | Not always | Nausea, moderate, 1 to 3 days | 91.5 kg |
| 4 | Lower, comfortable | Yes | Nausea, mild, improving | 91.6 kg |
| 5 | Lower, comfortable | Yes | None | 90.9 kg |
| 6 | Lower, comfortable | Yes | Constipation, mild | 90.4 kg |
Read on its own, week 4 looks like progress has stopped. Across six weeks the direction is clearer, and you can see that nausea appeared in week 3, eased in week 4 and was gone by week 5. That pattern is what makes a conversation with the health team more useful.
Appetite can vary from week to week. Track meal size, cravings, sufficient nutrition, hydration and the trend over time. Insufficient protein is not an established explanation for absent appetite suppression.
A lower appetite often brings a lower thirst, so you can end up drinking less without noticing. Drink on a schedule instead of waiting to feel thirsty. When you are eating less, include electrolytes (sodium, potassium, magnesium) through food, broth or an electrolyte drink. Check with your health team first if you have kidney or heart disease, take blood pressure medication or water pills, or have a fluid restriction.
Review several weeks of weight measurements rather than a single week. Consider changes in activity, eating patterns, sleep, constipation and fluid balance. A plateau alone does not establish a need for a higher dose, but one lasting several weeks with no negative symptoms is a fair reason to ask your health team about the options.
Compare tolerability and trends with earlier weeks. Watch for persistent GI symptoms, skin sensitivity, fatigue and heart-rate changes. Escalation is never automatic based on the current dose or number of weeks.